Research Study #22

Weissella cibaria CMU exerts an anti-inflammatory effect by inhibiting Aggregatibacter actinomycetemcomitans-induced NF-κB activation in macrophages

Conclusions

The present study demonstrated the anti‑inflammatory effects of the oral cavity‑derived probiotic oraCMU, indicating its usefulness as a prophylactic oral probiotic. OraCMU inhibited proinflammatory signaling in A. actinomycetemcomitans‑induced macrophages by blocking NF‑κB activation, resulting in decreased phosphorylation of IKKs and IκBα, decreased translocation of p65 to the nucleus and decreased expression of iNOS, IL1β and IL6. Although further in vivo research will be required to confirm the anti‑inflammatory effects of this strain, these results provide molecular evidence for the immunomodulatory effects of oraCMU. Overall, the findings of present study indicated that oraCMU could be used to develop oral care probiotics that can aid in the prevention of periodontal disease. The effects of live probiotics were investigated in the present study. Comparative studies on live and dead oraCMU in a further study might be meaningful and should be considered in further research.